This document presents the programme of work for the United Nations Environment Programme (UNEP) for the biennium 2022-2023, along with the associated budget. The programme of work sets out the UNEP results framework for the biennium, focused on the three strategic objectives outlined in the medium-term strategy. Overall, the programme of work shows how the UNEP thematic subprogrammes (supported by the enabling and foundational subprogrammes) will drive the transformational shifts targeted by the medium-term strategy for 2022-2025; outlines the means of measuring the effectiveness of UNEP in its direct, enabling and influencing roles; and defines a timebound trajectory that aligns the organization with the 2030 Agenda. The three thematic subprogrammes will work towards a set of 2025 outcomes, supported by relevant indicators for measuring the results achieved in an integrated and focused manner that takes into account the contributions of the foundational and enabling subprogrammes to sustainable consumption and production.