The present report provides an overview of overarching activities undertaken by the Partnership during the period from December 2020 to February 2022, including on work conducted in a cross-cutting manner amongst Partnership areas pursuant to decisions of the Partnership Advisory Group (PAG), as well as intersessional work for the fourth meeting of the Conference of the Parties to the Minamata Convention. On the basis of input received from each Partnership area, it also presents highlights of Partnership areas activities during the reporting period, as well as some of the future work planned.