The purpose of this monograph is 2-fold: 1) to provide descriptive guidance for JECFA and JMPR to ensure the continuation of transparent and sound expert evaluations of scientific data for risk assessments of chemicals in food; and 2) to be informative for users of the outputs from JECFA and JMPR, such as risk managers and other risk assessment bodies in Member countries and authorities. The monograph addresses the key issues considered by JECFA and JMPR in their food chemical risk assessments, as summarized below