This study looks at the 124 countries that participated in the UNEP-GEF Project for Development of National Biosafety Frameworks (NBF), hereinafter referred to as the NBF development project, as well as the 8 countries that participated in the UNEP-GEF demonstration projects for the implementation of the NBFs, hereinafter referred to as the 8 demonstration implementation projects, focussing on a comparative analysis of their experiences in order to draw out lessons and best practices applicable to other global initiatives for implementation of MEAs. These projects are implemented by UNEP under the GEF Initial Strategy for assisting countries to prepare for entry into force of the CPB.