A healthy environment is a precondition for achieving the Sustainable Development Goals. To be able to meet environmental objectives, Governments need accurate and reliable environmental data. In Colombia, the work was based on the interaction of the targets of the Sustainable Development Goals as identified using the Sustainable Development Goals Synergies analytical tool developed by the Stockholm Environment Institute. Emphasis was placed on implementation of the Sustainable Development Goals at the subnational level and on the response to the coronavirus disease (COVID-19) pandemic.