The OzonAction informal prior informed consent mechanism (iPIC) 2021 annual report provides a concise summary of the operation of iPIC queries in 2020 as well as providing a summary of data from the last decade to show the evolution of the platform and the new features of the upgraded platform. This report is intended to present iPIC’s successes and encourage further usage of the platform both from new users and to inspire current members to further engage in the iPIC process. iPIC was developed and is maintained by OzonAction to assist countries to better manage trade in ODS that are controlled under the Protocol; to facilitate and monitor ODS trade and avoid illegal or unwanted shipments. iPIC is a secure, restricted platform that currently has 127 member countries.