This document summarizes the key findings of a study exploring the potential contributions of UNEP’s Regional Seas Programme to the implementation of the Convention on Biological Diversity’s post-2020 global biodiversity framework (GBF). A case is made to make best use of UNEP’s Regional Seas Programme for the Post-2020 Global Biodiversity Framework (GBF) under development by the Convention on Biological Diversity (CBD). Key findings are based on an overview of the work of the Regional Seas Conventions and Action Plans (RSCAPs) of relevance to the GBF, highlighting the RSCAPs’ potential for addressing and strengthening the marine and regional outlook of the GBF. Recommendations are made to the CBD, UNEP/RSP, RSCAPs and States on their mutually reinforcing roles in supporting a regional biodiversity dimension.