The guidance is designed to assist the governments of developing countries (“Article 5 countries” under the Montreal Protocol on Substances that Deplete the Ozone Layer) in devising strategies for digital solutions in electronic import/export licensing systems to enhance monitoring, reporting, verification, and enforcement (MRVE) of licensing system of controlled substances under the Montreal Protocol. The key functions of these systems include facilitating interactions and information sharing among licensing authorities, importers, exporters, and Customs. The target audience is government officers responsible for operating licensing systems for substances controlled under the Montreal Protocol. The guidance offers an overview of available options and recommendations for Ozone-Depleting Substances (ODS) and hydrofluorocarbon (HFC) import/export control processes and how to integrate them with other online systems used for national-level international trade.