Pollution today is pervasive and persistent. While the world has achieved significant economic growth over the past few decades, it has been accompanied by large amounts of pollution, with significant impacts on human health and ecosystems and the ways in which some of the major Earth system processes, such as the climate, are functioning. This report describes the pollution challenge, explores what is already being done to address pollution, and proposes 50 focused and actionable interventions to address pollution in all its forms. The report is a call to act towards a pollution-free planet.