The creation of new protected areas or the expansion of existing ones, especially in zones where conservation and resilience potentials are high, their inclusion in landscape approaches and the implementation of strategies that strengthen connectivity within the biome, become fundamental actions to enable biodiversity to adapt to climate change and for maintaining the supply of ecosystem services in the long term in the Amazon biome. Governance and policy-making processes for conserving the Amazon should include climate change and resilience criteria for planning and managing protected areas systems in the region and consider the need for a stronger socio-institutional adaptive capacity that can facilitate natural processes for adapting to climate change.