Within the context of the UN Secretary-General’s Climate Action Summit and the focus of establishing a coalition for nature-based solutions, we would like to introduce the Food Agriculture Biodiversity Land and Energy (FABLE) Consortium as a model-aided decision-support environment for sustainable development pathways in the land-use space. Through its focus on systems-based approaches and integrated assessments, FABLE can help advancing the understanding how strategic decisions concerned with scaling up nature-based solutions can benefit the overall transformation of food and land-use systems towards sustainability. This will improve insights into interactions between regional and country scale proposals with global scale concerns.