The 1972 United Nations Conference on the Human Environment in Stockholm marked a watershed moment. Recognizing the centrality of the environment for human well-being, it spawned environment ministries and agencies worldwide, created a host of new global agreements to protect the environment, and recognized the need for an anchoring institution in the United Nations – the UN Environment Programme (UNEP). Five decades after the Stockholm Conference made the link between environment and poverty; thirty years after Rio chartered sustainable development; and seven years after the world adopted the 2030 Agenda, Stockholm again welcomes the world in 2022. Anchored in the Decade of Action, the theme of the international meeting is “Stockholm+50: a healthy planet for the prosperity of all – our responsibility, our opportunity.” This note speaks to the organizing principles of engagement – Implementation, Interconnection and Intergenerational; and 5 Rs - pathways to a healthy planet which will help frame the Leadership Dialogues and consultations and serve as guidance for commitments and actions. Based on the UN General Assembly Resolution 75/326, the leadership dialogues will address the following themes: Leadership Dialogue 1: Reflecting on the urgent need for actions to achieve a healthy planet and prosperity of all. Leadership dialogue 2: Achieving a sustainable and inclusive recovery from the COVID-19 pandemic. Leadership Dialogue 3: Accelerating the implementation of the environmental dimension of Sustainable Development in the context of the Decade of Action.