This policy guidance serves two purposes: • To highlight key features of urban agriculture taking an urban-rural systems perspective, drawing on a synthesis literature review across regions of the world to address urban agriculture’s potential to advance multiple sustainability outcomes. • To develop a road map for designing “fit-for purpose” urban agriculture policies, taking a systems perspective to respond to different drivers and policy objectives, addressing multiple sustainability goals related to nutritional equity, environmental sustainability, economic development, and community health and well-being.