This Navigating New Horizons report outlines a process focused on planetary health and human wellbeing—an intentional framing to expand the range of issues and informed views that typically shape UNEP’s work. Why? To ensure we are looking in places not normally considered, but where the organization can act or provide advice for others with relevant portfolios. This 18-month foresight process—which encompassed a two-part Delphi survey, the development of scenarios, sensemaking at global and regional levels and engaging with youth voices—has resulted in diverse data points and qualitative feedback to uncover what the future (near and far) could hold for planetary health and human wellbeing.