This Framework Manual introduces, in a structured way, various facets of green and sustainable chemistry, with the intention to foster general learning, reflection and scaling- up action based on a common global understanding of the concept. It features an organizing framework that unpacks various topics relevant in green and sustainable chemistry literature. Objectives and guiding considerations are offered to stimulate stakeholder action at various levels and in different settings. Ultimately, the Manual seeks to promote chemistry innovation that unveils the full potential of chemistry that is compatible with and supports the implementation of the 2030 Sustainable Development Agenda.