In its decision 4/1, the United Nations Environment Assembly of the United Nations Environment Programme (UNEP) requested the Executive Director of UNEP to submit for consideration and approval by the Environment Assembly at its fifth session, in consultation with the Committee of Permanent Representatives, and building on lessons learned from previous bienniums, a results-oriented and streamlined Medium-Term Strategy and programme of work in line with General Assembly resolution 72/266. UNEP’s Medium-Term Strategy for 2022—2025, and the programme and work and budget for 2022–2023, focus on responding to three planetary crises - climate change, biodiversity and nature loss, pollution and waste. Tackling these challenges to achieve climate stability, living in harmony with nature and moving towards a pollution-free planet will require a recalibration of our economies and societies towards more sustainable and equitable models. The Medium-Term Strategy outlines a set of transformative shifts that target the drivers of climate change, biodiversity loss and pollution, and looks at their impact. It maps out the actions needed to reshape our consumption and production patterns towards sustainability, framing UNEP’s contribution in the context of the 2030 Agenda for Sustainable Development and the Decade of Action to deliver the Sustainable Development Goals and beyond. It does so while respecting synergies with the Multilateral Environmental Agreements and in line with their relevant objectives, goals and principles, without prejudice to the outcome of future negotiations. The Medium-Term Strategy will also guide the support provided by UNEP in a manner consistent.