Water scarcity and water pollution pose a critical challenge in many developing countries. In urban areas, it is becoming difficult for the authorities to manage water supply and wastewater. Strategies for water and wastewater reuse can improve urban water management. This publication provides introductory guidelines for these strategies. The important aspects to minimize public health risks are identified. The possibilities of wastewater reuse in agriculture, industry, urban uses, and environmental water enhancement including groundwater recharge are discussed with the help of practical examples. The capacity building policy-making, institutional strengthening, financial mechanisms, and awareness raising and stakeholder participation are vital to implement these strategies for wastewater reuse.