While the Measuring Progress: Environment and the SDGs (2021) report focused on understanding the interlinkages through a statistical correlation analysis, the proposed methodology herein will further develop the statistical correlation analysis of one thematic area into a multivariable analysis by including additional socioeconomic and environmental factors that might impact the relationship between the analysed indicators. The main objective is to use the driver-pressure-state-impact-response (DPSIR) framework to investigate the relationship between actions taken by countries and their impacts on freshwater- and marine-related ecosystems as well as secondary impacts on human well being through the lens of the SDG indicators. The methodology enables analysis of the potential impacts on freshwater- and marine-related ecosystems separately and includes different geographical levels, based on data availability.