The present report provides an overview of overarching activities undertaken by the Partnership during the period from December 2020 to October 2022, including on work conducted in a cross-cutting manner amongst Partnership areas pursuant to decisions of the Partnership Advisory Group (PAG), as well as work in support to decisions of the Conference of the Parties to the Minamata Convention. On the basis of input received from each Partnership area, it also presents highlights of Partnership areas activities during the reporting period, as well as some of the future work planned.